One potential problem may show itself when allowing the collector voltage to get near the Vcc rail -- nearly zero collector current. Which means the dynamic range, the ratio of maximum (or quiescent) current vs this minimum (near zero), potentially impacts signal-driven gain variation enough to lead to unwanted distortion. It's often worth a moment to look at the dynamic range of collector current over signal variation in any specific incarnation of a single stage and think about leaving some top-end margin, too.
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